US top diplomat will meet Egypt's President Abdel Fattah el-Sisi and Foreign Minister Sameh Shoukry in Cairo.
Pompeo will meet Egypt's President Abdel Fattah el-Sisi and Foreign Minister Sameh Shoukry on Thursday to discuss security and economic cooperation.
He will also to deliver a speech on Washington's broader Middle East objectives.
Pompeo arrived in Egypt after stops in Jordan and Iraq where he sought to assure leaders that withdrawing from Syria does not mean the US is abandoning the fight against the Islamic State of Iraq and the Levant (ISIL, also known as ISIS) armed group or easing pressure on Iran.
He has chosen Cairo as the symbolic venue for the speech seemingly intended to repudiate the message in former US President Barack Obama's landmark address to the Muslim world from the Egyptian capital when he first took office.
Obama pledged engagement with Iran and an understanding of the need for freedom and democracy that led to the Arab Spring revolutions.
Pompeo intends to assert the Trump message that Iran is to be countered at all costs, while assuring that the US remains deeply committed to the region despite the America First rhetoric emanating from the White House.
In Saudi Arabia, he faces the thorny problem of dealing with global outrage against Saudi Crown Prince Mohammad bin Salman (also known as MBS), accused of conspiring to murder Washington Post columnist Jamal Khashoggi.